Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity

Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity

Endothelium-derived nitric oxide (NO) generated by endothelial NO synthase (eNOS) is a key regulator of endothelial function. Vascular NO induces vasodilation, inhibits platelet aggregation and adhesion, prevents oxidative modification of LDL cholesterol, limits vascular smooth-muscle-cell proliferation, and decreases the expression of proinflammatory genes that promote the development of ather...

Anti-atherosclerotic effects of small molecular weight compounds enhancing eNOS expression and preventing eNOS uncoupling

Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms.

ADP mediates platelet-induced relaxation of blood vessels and may function as an important intercellular signaling molecule in the brain. We used pharmacological and genetic approaches to examine mechanisms that mediate responses of cerebral arterioles to ADP, including the role of endothelial nitric oxide synthase (eNOS). We examined responses of cerebral arterioles (control diameter approxima...

Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation.

Diesel exhaust particles cause an impairment of endothelium-dependent vasorelaxation and are associated with cardiopulmonary-related diseases and mortality, but the mechanistic details are poorly understood. Since we reported previously that phenanthraquinone, an environmental chemical contained in diesel exhaust particles, suppresses neuronal nitric oxide synthase (nNOS) activity by shunting e...

Molecular mechanisms underlying activity-dependent regulation of BDNF expression.

Activity-dependent changes in synaptic strength, which appear to underlie cortical plasticity, require long-lasting biochemical changes in the postsynaptic neuron. An inductive event common to several forms of synaptic plasticity is an influx of calcium into the postsynaptic cell. Calcium acts as a second messenger to set into motion a cascade of biochemical signaling events that leads to new g...